The head of NBC entertainment encouraged Aniston to continue acting, and a few months later helped cast her for Friends, but Courteney Cox was considered to be better suited to the role. She was also offered a spot as a featured player on Saturday Night Live, but turned it down to do Friends.1 million per episode for the last two seasons of Friends, as well as five Emmy nominations (two for Supporting Actress, three for Lead Actress), including a win for Outstanding Lead Actress in a Comedy Series.She was also nominated for two Golden Globe Awards and won, in 2003, the Golden Globe Award for Best Actress – Television Series Musical or Comedy.

Wesley Morris of The Grantland called her "one of the great screen comedians.

[...] Most of her scenes here are extraneous, but her vulgarity and tartness are so sharp that the movie needs them.

Gregory Ellwood of Hit Fix stated, "It's really on most people's radar for being a rare dramatic turn for Jennifer Aniston, and she doesn't disappoint." He further stated, "Aniston makes you believe in Claire's pain.

She makes you believe this character is at her lowest point and only she can pull herself out of it.

She is the daughter of Greek-born actor John Aniston and American actress Nancy Dow.

Aniston gained worldwide recognition for portraying Rachel Green on the television sitcom Friends (1994–2004), a role which earned her a Primetime Emmy Award, a Golden Globe Award, and a Screen Actors Guild Award.

Aniston starred in the comedy movie Horrible Bosses (2011), with Colin Farrell, Jason Bateman, Charlie Day, and Jamie Foxx, directed by Seth Gordon.

The film focuses on a trio of employees who plot to murder their titular tyrannical supervisors.

Her box office hits include Bruce Almighty (2003), The Break-Up (2006), Marley & Me (2008), Just Go with It (2011), Horrible Bosses (2011), and We're the Millers (2013), each of which have grossed over Her most critically acclaimed roles included the role of Olivia in Friends with Money (2006), The Good Girl (2002), for which she was nominated for an Independent Spirit Award for Best Female Lead, and the drama Cake (2014), for which she received nominations for the Golden Globe Award and the Screen Actors Guild Award for Best Actress.

Her other films include Along Came Polly (2004) and He's Just Not That Into You (2009).

In 2001, Aniston was in Melissa Etheridge's music video for "I Want To Be In Love".