One of many relationships the show delved into was the one between Nick and Lindsay.In real life, the romance between Jason Segel and Linda Cardellini outlasted the series, which was canceled long before its time.Since the beginning of their Riverdale romance, "Bughead fans" everywhere have been hoping that the chemistry between Cole Sprouse and Lili Reinhart comes from a real life relationship.

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Well, at least one person let Isaac in: Crystal Reed.

She began dating Daniel Sharman during the show’s second season.

This is why many people in any profession choose not to form romantic relationships with coworkers.

Every one of these couples had amazing chemistry and helped define love for generations of viewers.

Another much debated topic among fans was whether Joey belonged with Pacey or Dawson.

According to Kevin Williamson, the chemistry between Katie Holmes and Joshua Jackson was apparent early on, which is how he decided that the relationship between Joey and Pacey would eventually turn romantic.

In terms of One Tree Hill, did you feel that Lucas belonged with Brooke or Peyton?

These were - and still are - divisive issues for many fans.

Sometimes, life imitates art and the actors find themselves with the same feelings as their fictional counterparts.