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Weight Loss. Do Diet and Exercise Really Make You Fat? Experts Respond to the TED Talk People Are Buzzing About. Weight loss issues related to specific diseases include: As chronic obstructive pulmonary disease (COPD) advances, about 35% of patients experience severe weight loss. Weight loss can be intentional, such as from dieting and exercise, or unintentional and be a manifestation of illness. Weight loss can result from a decrease in body.